You’ve got the materials (maybe even picked them up at U4GM), summoned Uber Andariel, and now you’re standing face to face with one of D4 Materials for Sale’s most brutal bosses.
Now what?
This guide will walk you through everything you need to survive and dominate your battle with Andariel—whether you’re aiming for regular Uber or the terrifying Tormented version.
Who Is Andariel?
The Maiden of Anguish is one of the original Prime Evil’s siblings. She’s fast, brutal, and laced with poison-based attacks and mechanics that can wear down even the best players.
In Diablo 4, Andariel’s boss arena is chaotic and filled with adds (summoned enemies), ground hazards, and deadly AoE poison pools. Bring your A-game.
Andariel Boss Fight Mechanics
Understanding her moves is half the battle. Here’s what to expect:
? Poison Nova
She releases a wave of poisonous gas that deals damage over time. If you’re not rocking poison resistance or defensive buffs, this can wipe you.
?️ Web Trap
She casts webbing on the floor, slowing movement and trapping players in AoE zones. Kite her and avoid getting stuck.
? Add Summons
Throughout the fight, Andariel will summon spiderlings and corrupted cultists to flood the arena. If ignored, they’ll overwhelm you.
? Enrage Phase
At low HP, she becomes much more aggressive, using back-to-back attacks with increased movement speed and damage. This is the “burn” phase—you want her dead before she melts your team.
Builds That Work Well Against Andariel
Different classes need different strategies, but here are some general builds that shine:
? Barbarian – “Thorns & Bleed” Build
High survivability.
Passive AoE damage to clean up adds.
Strong against poison with Iron Skin and Fortify mechanics.
? Sorcerer – “Ice Shards” or “Chain Lightning”
Huge burst potential.
Use Teleport + Ice Armor to escape poison zones.
Focus on chilling/freezing to control add spawns.
?️ Rogue – “Shadow Imbuement” or “Twisting Blades”
Incredible single-target damage.
Use smoke grenades and dash to avoid AoEs.
Ideal for burst in the Enrage phase.
? Necromancer – “Bone Spear” or “Shadow Minions”
Bone Spear deletes bosses.
Use minions as distractions for summoned enemies.
Corpse Tendrils + Shadowblight for control and DPS.
? Druid – “Werewolf Tornado” or “Pulverize”
Strong tankiness, great sustain.
Cyclone Armor to resist poison.
Summons to help tank adds.
Make sure your resistances, damage over time mitigation, and mobility are strong for this fight.
Prepping for the Fight
Before even entering the arena, make sure to:
Use Elixirs – Especially poison resistance, or anything that boosts damage and health regen.
Stack Up on Potions – You’ll need every healing opportunity you can get.
Socket Gems Wisely – Think Topaz (damage reduction while control-impaired) or Amethyst (damage reduction over time).
Craft Your Sigils – If you’re summoning her from a specific tiered dungeon, make sure it matches your power level.
How U4GM Helps Here
If you don’t want to farm bosses like Lord Zir, The Beast in the Ice, or The Pit over and over for materials, U4GM offers an instant shortcut.
Here’s how that makes a difference:
Save prep time – You can focus on builds and mechanics, not materials.
Multiple attempts – Buy enough mats for several runs and practice the fight without farming in between.
Unlock top-tier loot faster – Andariel has a chance to drop Mythic Uniques like Shako and Andariel’s Visage—you’ll want multiple cracks at it.
Pro Tips for Success
Bring a squad if you’re not 100% confident solo. Coordination helps during the Enrage phase.
Clear adds fast – Ignoring them is how things spiral out of control.
Don’t panic during poison – Save mobility cooldowns for when she floods the arena with toxic clouds.
Burn hard at 25% HP – The final phase is fast-paced and unforgiving.
Final Thoughts
Beating Andariel is a massive accomplishment in Diablo 4 items. It’s also one of the most rewarding PvE experiences in the game. But don’t let farming for her summoning materials slow you down. With services like U4GM, you can skip the grind, summon her on-demand, and focus on the fight—not the farm.
